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KMID : 0374920170380010025
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Inje Medical Journal
2017 Volume.38 No. 1 p.25 ~ p.33
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Effect of Ventricle Size on Development of Freezing of Gait in Parkinson’s Disease
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Lee Jae-Jung
Song Pamela
Cho Joong-Yang
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Abstract
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Background and purpose: A freezing of gait (FOG) is a disabling motor symptom in Parkinson’s disease (PD) which is hardly understood so far. There have been neither effective treatment nor known certain risk factor for occurrence of this mysterious phenomenon. We sought to evaluate the whether enlarged intracranial ventricle could predict the development of FOG in patients with PD.
Methods: This study included respective age matched PD with (n = 16) or without FOG (n = 16) subjects. Quantitative parameters for intracranial ventricle include Evans’ ratio, thickness of corpus callosum, and coronal angle of corpus callosum.
Results: The PD with FOG group showed more increased Evans’ ratio (0.33 ± 0.14 vs 0.26 ± 0.09, p = 0.015)and thinner thickness of corpus callosum (5.31 ± 2.37 vs 7.81 ± 3.62 mm, p < 0.001) than those of the PD without FOG group. A thinner corpus callosum was strongly implicated to occurrence of FOG (Odds ratio (OR), 0.897; standard error(SE), 0.007; p = 0.014), while a trend without significance was observed on Evans’ ratio (OR, 1.125; SE, 0.248; p = 0.074).
Conclusions: The enlarged ventricle might contribute to occurrence of FOG in PD. A thorough assessment of ventricle parameters at early stage of PD is likely to predict the presence or absence of future FOG.
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KEYWORD
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Parkinson’s disease, Freezing of gait, Ventriculomegaly
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